Macrophagic myofasciitis (MMF) is a rare, seemingly emerging entity among adult patients in France. We encountered two children with the first two cases of MMF in North America.
Both children received age-appropriate immunizations. Quadriceps muscle biopsy from each child showed the typical… infiltration of… macrophages with adjacent myofiber atrophy…
A single aluminum peak was demonstrated on energy dispersive X-ray microanalysis.
The etiology of the clinical symptoms in these cases and in cases reported as MMF remains intriguing. Despite numerous stains to demonstrate organisms, most infectious causes leading to macrophage activation were ruled out.
These cases are being reported to increase awareness of this condition and to encourage a systematic epidemiologic and clinicopathologic study in North America.