In the present study, alum, alum-containing vaccine and alum adjuvant… were used to evaluate i) the persistence time at the injection site, ii) the translocation of alum from the injection site to lymphoid organs, and iii) the behavior of adult CD1 mice following intramuscular injection of alum (400 μg Al/kg).
Alum-induced granuloma remained for a very long time in the injected muscle despite progressive shrinkage from day 45 to day 270.
[A]n additional experiment was done, and showed early brain translocation at day 45 of alum injected subcutaneously at 200 μg Al/kg.
This study confirms the striking biopersistence of alum.