Asymptomatic Transmission & Shedding

Inactivated Polio Vaccine Does Not Prevent Infection or Transmission

Captured 2023-03-10
Document Highlights

As IPV [inactivated polio vaccine] is not a ‘live’ vaccine, it carries no risk of VAPP [vaccine-associated paralytic polio].

IPV induces very low levels of immunity in the intestine. As a result, when a person immunized with IPV is infected with wild poliovirus, the virus can still multiply inside the intestines and be shed in the faeces, risking continued circulation.

An increasing number of industrialized, polio-free countries are using IPV as the vaccine of choice. This is because the risk of paralytic polio associated with continued routine use of OPV is deemed greater than the risk of imported wild virus.

However, as IPV does not stop transmission of the virus, OPV is used wherever a polio outbreak needs to be contained, even in countries which rely exclusively on IPV for their routine immunization programme.