Initial U.S. Approval: 1978
M-M-R II is a vaccine indicated for active immunization for the prevention of measles, mumps, and rubella.
There is a risk of fever and associated febrile seizure in the first 2 weeks following immunization with M-M-R II vaccine.
Individuals with a history of anaphylactic, anaphylactoid, or other immediate reactions… subsequent to egg ingestion may be at an enhanced risk of immediate-type hypersensitivity reactions after receiving M-M-R II vaccine.
[T]hrombocytopenia has been reported within 4-6 weeks following vaccination with measles, mumps and rubella vaccine.
ADVERSE REACTIONS
– Panniculitis; atypical measles; fever; syncope; headache; dizziness; malaise; irritability.
– Vasculitis.
– Pancreatitis; diarrhea; vomiting; parotitis [mumps]; nausea.
– Diabetes mellitus*
– Thrombocytopenia; purpura; regional lymphadenopathy; leukocytosis.
– Anaphylaxis, anaphylactoid reactions, angioedema (including peripheral or facial edema) and bronchial spasm.
– Arthritis; arthralgia; myalgia.
– Encephalitis; encephalopathy; measles inclusion body encephalitis (MIBE) subacute sclerosing panencephalitis (SSPE); Guillain-Barré Syndrome (GBS); acute disseminated encephalomyelitis (ADEM); transverse myelitis; febrile convulsions; afebrile convulsions or seizures; ataxia; polyneuritis; polyneuropathy; ocular palsies; paresthesia.
– Pneumonia; pneumonitis; sore throat; cough; rhinitis.
– Stevens-Johnson syndrome; acute hemorrhagic edema of infancy; Henoch-Schönlein purpura; erythema multiforme; urticaria; rash; measles-like rash; pruritus; injection site reactions (pain, erythema, swelling and vesiculation).
– Nerve deafness; otitis media [ear infection].
– Retinitis; optic neuritis; papillitis; conjunctivitis.
– Epididymitis; orchitis.
– Death*
[R]ubella virus propagated in WI-38 human diploid lung fibroblasts.
Each dose is calculated to contain… recombinant human albumin… fetal bovine serum…
M-M-R II vaccine has not been evaluated for carcinogenic or mutagenic potential or impairment of fertility.